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- W2385731829 abstract "Objective Intrinsic and/or acquired resistance is the major obstacle to overcome in the treatment of patients with breast cancer.The aimof the present study was toinvestigate the relationship betweenthe expression of multidrug resistance-associated protein 1(MRP1)withthe clinicpathological characteristics andthe prognosisin primary breast cancer patients.Methods Expression of MRP1in60 breast can-cer patients was determined byimmunohistochemistry on formalin-fixed,paraffin-embedded tumor section.Results(1) MRP1expressionwas observedin 51 of 60(85.0 %).(2)MRP1expression was more frequently observedin patients withlymph nodemetastasis.No relation canbe established between expression of MRP1and other clinicophathological parameters.(3)Kaplan-Meier analyses revealedthat MRP1expres-siononly associated with disease-free survival(DFS) and didn’t with overall survival(OS).(4) In multivariate Cox regressionanalyses,MRP1expression didn’t associate with DFS,and OS.In addition,tumor size,lymph node metastasis and ER were independent prog-nostic factors for DFSand OS(P0.05).Conclusion Our results suggestedthat MRP1isfrequently expressionin primary breast cancer,butMRP1is not a poor prognostic factor in patients with breast cancer." @default.
- W2385731829 created "2016-06-24" @default.
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- W2385731829 date "2006-01-01" @default.
- W2385731829 modified "2023-09-23" @default.
- W2385731829 title "The Prognostic Significance of Multidrug Resistance-associated Protein 1(MRP_1) Expression in Primary Breast Carcinoma" @default.
- W2385731829 hasPublicationYear "2006" @default.
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