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- W2385744931 abstract "Objective:To compare the efficacy of patient-controlled intravenous analgesia (PICA) with a co-application of different dosage of tramadol and fentanyl in postoperative analgesia in children.Methods:By an observer-blinded design, 120 ASA Ⅰ~Ⅱ pediatric patients (1~12 years old) underwent general anesthesia were randomly given a postoperative intravenous infusion of 1% tramadol (Group T), 1% tramadol plus fentanyl 2 μg/ml (Group TF1) , 1% tramadol plus fentanyl 4 μg/ml (Group TF2) , or 1% tramadol plus fentanyl 6 μg/ml (Group TF3 ).Exclusion criteria included children with mental disorders, hypothyroidism pilepsy, and long-term analgesic users. All the patients received Granisentran Hydrochloride 40 μg/kg via intravenous injection at the end of surgery. PCIA was commenced and continued for 24 h. The analgesic effect was assessed by Wong-Baker Faces Pain Rating Scale (FRS) and the Children's Hospital of Ontario Pain Scale (CHEOPS), less than 4 (no pain), more than 6 (moderate pain), more than 13 (severe pain), consumption of analgesics and the incidences of side-effects were recorded.Results:(1)There were no significant differences in the demographic data including sex, age, body weight, types of surgery and duration of operation among the four groups (P0.05); (2) No significant differences were found in BP, HR, RR (respiratory rate) and SpO2 among the four groups (P0.05); (3) The FRS did not significantly change among the four groups, and the CHEOPS at the point of 30 min were significantly decreased in both group T and group TF1; (4)With the dosages of fentanyl increased, the 24 h consumptions of tramadol were significantly reduced in Group T , Group TF1 and Group TF2 (P0.05), but the tendency was disturbed in Group TF3; (5)The incidences of vertigo, nausea and vomiting had no significant differences among the four groups, while the recovery time of Group TF3 was significantly longer than that of the other three groups.Conclusion:A co-application of small dose of fentanyl and tramadol may produce more effective and safe PCIA in children. Meanwhile, demand of tramadol was reduced.Optimal combination may be 1% tramadol adding fentanyl 4 μg/ml, administering plan was loading dose of 0.1 ml/kg, continuous infusion of 0.5~1 ml/h, PCA dose of 0.5~1 ml.By the way, the safety of Granisetron in using of children is remain to be investigated." @default.
- W2385744931 created "2016-06-24" @default.
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- W2385744931 date "2007-01-01" @default.
- W2385744931 modified "2023-09-25" @default.
- W2385744931 title "Postoperative intravenous analgesia with a combination of tramadol and fentanyl continuously infused in children" @default.
- W2385744931 hasPublicationYear "2007" @default.
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