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- W2385750093 abstract "Objective To study on the effect of p53、bcl-2、bax in apoptosis of cultured human hepatocyte HL-7702 induced by glycodeoxycholate(GCDC) and to explore its possible mechanism.Methods HL-7702 cells were incubated with various concentrations(100、150、200、250μmol/L) of GCDC for 24h.The apoptotic rate of HL-7702 was determined by AnnexinⅤ-FITC/PI double staining.The mRNA expression levels of p53、bcl-2/bax in HL-7702 cells were analyzed by RT-PCR.ResultsHL-7702 cells could be induced to undergo apoptosis in a concentration dependent manner after 100μmol/L、150μmol/L、200μmol/L、250μmol/L GCDC treatment for 24 hours.The apoptotic rates were(13.16±2.9)%,(20.3±3.0)%,(25.02±2.1)%and(45.02±3.5)%,which were markedly higher(P0.05)than that of the control group.The expression of p53、bax mRNA were increased and the expression of bcl-2 mRNA was decreased.Conclusion p53、bcl-2 and bax play an important role in apoptosis of cultured human hepatocyte HL-7702 induced by GCDC." @default.
- W2385750093 created "2016-06-24" @default.
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- W2385750093 date "2013-01-01" @default.
- W2385750093 modified "2023-09-25" @default.
- W2385750093 title "Study on the effect of p53、Bcl-2、Bax in apoptosis of cultured human hepatocyte HL-7702 induced by glycodeoxycholate" @default.
- W2385750093 hasPublicationYear "2013" @default.
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