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- W2385778873 abstract "Objective The primary purpose of this study was to investigate the association between the C270T polymorphism of brain-derived neurotrophic factor gene(BDNF) and ventricular enlargement as well as minor physical anomalies(MPA) in childhood schizophrenia.Methods The C270T polymorphisms of BDNF gene were genotyped in 204 childhood schizophrenia and 210 normal comparison subjects using polymerase chain reaction(PCR) methods and restriction fragment length Polymorphism(RFLP) typing.The volume of brain ventricles were evaluated using cerebral computed tomography(CT) examination and the minor physical anomalies were examined using Waldrop Scale(WS).Results ① The frequency of the C/T and T/T genotype as well as T allele were significantly higher in Childhood schizophrenia compared with the controls(X2=24.56,P0.01;X2=24.04,P0.01).②There was no significant difference in volume of brain ventricles among patients with different genotypes(P0.05).The Huckman's value was higher in patients with combination of C/T and T/T genotype than in patients with C/C genotype [(5.51±0.56) vs(5.31±0.50),t=2.28,P0.05).③ The total score of WS and the score for hand were higher in patients with combination of C/T and T/T genotype than in patients with C/C genotype(t=2.10,P0.05;Z=2.34,P0.05).④ Total score of WS was significantly positively correlated with Huckman's value as well as enlargement of third ventricle(r=0.26,P0.01;r=0.29,P0.01) and negatively correlated with index of anterior angle(r=-0.18,P0.05).Conclusions C270T polymorphism of brain-derived neurotrophic factor gene is associated with MPA as well as brain morphology in childhood schizophrenia." @default.
- W2385778873 created "2016-06-24" @default.
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- W2385778873 date "2009-01-01" @default.
- W2385778873 modified "2023-09-26" @default.
- W2385778873 title "The association between the C270T polymorphism of brain-derived neurotrophic factor gene and ventricular enlargement as well as minor physical anomalies in childhood schizophrenia." @default.
- W2385778873 hasPublicationYear "2009" @default.
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