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- W2385778895 abstract "Objective: To investigate the relationship between platelet activation and carotid intima -media thickness(IMT)in patients with impaired glucose tolerance (IGT).Methods: 76 patients with IGT were included and the level of platelet alpha granule membrane protein(Gmp-140)was measured in these patients. Meanwhile, IMT was observed with high resolution ultrasound. 35 healthy persons were enrolled as controls.Results: The levels of platelet GMP-140 and IMT were higher in the IGT group than those in the control group. Moreover, the level of platelet Gmp-140 in IGT patients with IMT≥ 0.9mm was significantly increased compared with that of IMT 0.9mm group (P0.01). Before and after oral 75g glucose loading for 2 hours, the changes of platelet Gmp-140 was higher in IMT≥ 0.9mm subgroup than that in IMT 0.9mm subgroup. Linear correlation analysis showed that the level of platelet GMP-140 was significantly correlated with the level of IMT. Stepwise linear regression analysis showed that platelet GMP-140 was an independent risk factor to the increasing carotid IMT. Conclusion:Platelet activation as well as carotid IMT was significantly increased in the patients with IGT, and oral glucose loading aggravate the increasing platelet activation.The platelet activation is an independent risk factor which accelerate carotid atherosclerosis." @default.
- W2385778895 created "2016-06-24" @default.
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- W2385778895 date "2005-01-01" @default.
- W2385778895 modified "2023-09-26" @default.
- W2385778895 title "Relationship between Platelet Activation and Carotid Intima-media Thickness in Patients with Impaired Glucose Tolerance" @default.
- W2385778895 hasPublicationYear "2005" @default.
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