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- W2385797822 abstract "【Objective】 To investigate the different effects induced by two administration methods of Methotrexate(MTX) to cervical cancer Hala cell,to explore a better treatment way.【Methods】 Three groups of Hela cells were cultured: blank,routine chemotherapy(MTX 12 mg/mL,72 h) and metronomic chemotherapy group(MTX 2 mg/mL,12 h /time,72 h for 6 times).MTT assay was used to assess the growth of Hela cell,Hoechst 33342/PI double staining to detect the apoptosis and death rate of Hela cell,RT-PCR to assess the expression levels of Caspase-3 of Hela cells in three groups.【Results】 The growth inhibition and apoptosis rates of the two MTX chemotherapy groups were higher than that of the blank one(P 0.01).The growth inhibition and apoptosis rates of the Hela cell in MTX metronomic chemotherapy group were higher than those in MTX routine chemotherapy one(P 0.01),but the death rate was lower in the former.The Caspase-3 expression of Hela cells in the two MTX chemotherapy groups were higher than that in the blank one,which in MTX metronomic chemotherapy group was higher than that in MTX routine chemotherapy group.【Conclusion】 The Methotrexate metronomic chemotherapy was higher efficiency and lower toxicity than the Methotrexate routine chemotherapy in cervical cancer Hela cell treatment." @default.
- W2385797822 created "2016-06-24" @default.
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- W2385797822 date "2012-01-01" @default.
- W2385797822 modified "2023-09-24" @default.
- W2385797822 title "Different effects induced by two administration methods of Methotrexate to the growth of cervical cancer HaLa cell" @default.
- W2385797822 hasPublicationYear "2012" @default.
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