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- W2385803019 abstract "Objective To evaluate the anticancer effect of arsenic trioxide (As 2O 3) on rabbits with hepatic Vx 2 carcinoma by transcatheter arterial infusion (TAI). Methods Rabbits with hepatic Vx 2 carcinoma were treated with As 2O 3 by TAI for 7 d consecutively. The tumor inhibitory rate and the average tumor weight were determined. The morphological changes of the tumor were observed with a transmission electron microscope. bax/bcl 2 and VEGF expressions were examined by immunohistochemistry. Results The average weight of the tumor was 7.99, 6.50, and 4.87 g, and the tumor growth inhibitory rates in the experimental groups were 50.31%, 59 58%, and 69 71%, respectively. Tumor growth was significantly inhibited as compared with that in the NS group ( P 0.05). The upregulated bax expression and downregulated bcl 2 expression were detected in As 2O 3 groups by immunohistochemistry. There was significant difference between the As 2O 3 groups and the control group ( P 0.05). Significantly decreased VEGF expression was also observed in As 2O 3 groups as compared with the controls ( P 0.05). Bcl 2 gene expression was consistent with VEGF expression. Transmission electron microscopy showed typical morphological characteristics of apoptosis of some tumor cells in the experimental groups. Conclusion As 2O 3 by TAI can inhibit rabbit hepatic Vx 2 carcinoma effectively in a dose dependent manner. Apoptosis induced by As 2O 3 may be closely related to the upregulated bax expression." @default.
- W2385803019 created "2016-06-24" @default.
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- W2385803019 date "2004-01-01" @default.
- W2385803019 modified "2023-09-23" @default.
- W2385803019 title "Experimental study of arsenic trioxide on rabbits with hepatic Vx-2 carcinoma by transcatheter arterial infusion" @default.
- W2385803019 hasPublicationYear "2004" @default.
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