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- W2385815147 abstract "Objective To study the protection of ashitaba chalcone(AC) on vascular endothelial cell injury in rats with type 2 diabetes mellitus(T2DM).Methods The rat models of T2DM-created by high-fat feeding plus intraperitoneal streptozotocin-were randomized to four groups as: control,high-dose-,middle-dose-and low-dose-AC,with 10 rats in each group.The rats in diabetic-control group were fed with high-fat diet and intragastric administration of distilled water,those in high-dose-,middle-dose-,and high-dose-AC groups were respectively offered AC of 30,10 and 5 mg/kg,intragastrically,and fed with common diet for four weeks.Serum endothelin-1(ET-1),VE-ca,fasting serum glucose and serum insulin were then measured.Results Compared with the control,the levels of blood glucose,serum insulin,serum ET-1 and VE-ca in rats of high-dose-AC group decreased(F=4.58-48.29,q=3.45-14.94,P0.05).Conclusion AC may reduce the levels of serum ET-1 and VE-ca and protect the endothelial cells of rats with type 2 diabetes." @default.
- W2385815147 created "2016-06-24" @default.
- W2385815147 creator A5017062372 @default.
- W2385815147 date "2013-01-01" @default.
- W2385815147 modified "2023-09-23" @default.
- W2385815147 title "THE EFFECT OF CHALCONES EXTRACTED FROM ANGELICA KEISKEI ON SERUM ET-1 AND VE-ca IN RATS WITH TYPE 2 DIABETES" @default.
- W2385815147 hasPublicationYear "2013" @default.
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