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- W2385823900 abstract "Objective To evaluate the effect of cyclophosphamide on the expression of insulin-like growth factor-I (IGF- I) and basic fibroblast growth factor (bFGF) in the testes and epididymides in the rats. Methods Ninety-six male adult rats (8 weeks old) were divided into 6 groups of 16 rats each. The cyclophosphamide of 10, 20, 40, 80 and 100 mg/ (kg'd) was given to the rats respectively in groups 1, 2, 3, 4 and 5. The group 6 serv as control received 2ml 0. 9% NaCl. All the rats were sacrificed and the levels IGF-I and bFGF in the epididymides and their expressions in the testes were determined by ELISA techniques and immunohistochemieal SP technique respectively 2 and 4 weeks after the administration of the drug. Results The levels of IGF-I and bFGF in the epididymides and their expression in the testes were gradually reduced with the increase in time after administration of the drug and dose of the drug in the rats. Conclusions Cyclophosphamide not only causes oligozoospermia or azoospermia, but also produces a significant decrease in the levels of IGF-I and bFGF of the epididymides and the expression of IGF-I and bFGF of the testes in the rats. The decrease in IGF-I and bFGF of testes and epididymides may be relative to the low spermatogeneous function of the testes caused by the administration of cyclophosphamide." @default.
- W2385823900 created "2016-06-24" @default.
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- W2385823900 date "2007-01-01" @default.
- W2385823900 modified "2023-09-25" @default.
- W2385823900 title "Changes in IGF-I and bFGF in Testis and Epididymis of Rats with Oligoazoospermia or Azoospermia Induced by Cyclophos-phamide" @default.
- W2385823900 hasPublicationYear "2007" @default.
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