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- W2385827410 abstract "Objective: The aim of this study was to investigate the effects of Zhengan Xifeng decoction on the spontaneous movement in 1-methy-4-phenyl-1,2,3,6-tetrahy-dropyridine(MPTP)-treated C57BL /6mice,and some mechanisms involved.Method: C57BL /6 mice were given MPTP(30 mg·kg-1) to prepare Parkinson disease mice model.Different doses of Zhengan Xifeng decoction(12.5,25,50 g·kg-1),or selegiline(10 mg·kg-1) were given for 14 d in the pretreatment groups.The behavioral analysis of C57BL/6 mice was performed by using spontaneous movement test.Real-time PCR and Western blot were used to analyze the expression of 14-3-3 and tyrosine hydroxylase(TH) mRNA and protein.Result: Zhengan Xifeng decoction could reduce the number of spontaneous movement of MPTP-treated C57BL /6 mice.Zhengan Xifeng decoction could also up-regulate the expression of 14-3-3 and TH mRNA and protein.Conclusion: Anti-Parkinson disease effect of Zhengan Xifeng decoction may be attributable to up-regulation mRNA and protein expression of 14-3-3 and TH in MPTP-treated C57BL /6 mice." @default.
- W2385827410 created "2016-06-24" @default.
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- W2385827410 date "2013-01-01" @default.
- W2385827410 modified "2023-09-23" @default.
- W2385827410 title "Effect of Zhengan Xifeng Decoction on Expression of 14-3-3and Tyrosine Hydroxylase Gene in Substantia Nigra of MPTP-treated C57BL /6 Mice" @default.
- W2385827410 hasPublicationYear "2013" @default.
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