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- W2385848431 abstract "[Objective]To investigate the effects of Qingdai Granules(QDG)on the expression of TLR2,TLR4 mRNAs in the colonic mucosa of rats with ulcerative colitis.[Methods]Ulcerative colitis was induced in rats by giving an enema of trinitrobenzene sulphonic acid(TNBS)and ethanol.Fifty two experimental animals were randomly divided into six groups:normal group,model group,sulfasalazine(SASP)group(500 mg/kg),and low,medium and high-dose QDG groups(600,900and 1 200 mg/kg).Except the normal group,the other groups were given intragastrically normal saline,SASP,and different concentrations of QDG,respectively,during the 3rd~12th days after model was established.Thereafter,rats were killed and the expression of TLR2 and TLR4 mRNAs in the colonic of rats was detected by reverse transcription-polymerase chain reaction(RTPCR).[Results]Compared with the normal group,the expression of TLR2 and TLR4 mRNAs in the colon of rats in the model group was significantly up-regulated.Compared with the model group,the expression of TLR2 mRNA in the colon of rats in the medium and high-dose QDG groups was significantly down-regulated and the expression of TLR4 mRNA in the high-dose QDG group was significantly down-regulated.[Conclusion]QDG can exert protective effects against rat ulcerative colitis perhaps by down-regulating TLR2 and TLR4 mRNAs expression." @default.
- W2385848431 created "2016-06-24" @default.
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- W2385848431 date "2011-01-01" @default.
- W2385848431 modified "2023-09-23" @default.
- W2385848431 title "Qingdai Granules down-regulate TLR2,TLR4 mRNA expression in the colonic mucosa of rats with ulcerative colitis" @default.
- W2385848431 hasPublicationYear "2011" @default.
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