Matches in SemOpenAlex for { <https://semopenalex.org/work/W2385852945> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2385852945 abstract "AIM: To study the effect of insulin sensitivity agonist—rosiglitazone on protein kinase B (PKB) expression of insulin resistant rats skeletal muscle. METHODS: Insulin resistant rat model was induced by high fat diet feeding. Thirty-nine male SD rats were randomly divided into two groups feeding either normal chow (NC, n=9) or high-fat diet(HF, n=30). After 2 mo, rats in group HF were randomly divided into three groups, high fat diet group (HFF, n=9), normal chow intervention group (HFN, n=9) and rosiglitazone intervention group (HFR, n=12). After 1 mo intervention treatment, all rats were fasted for 12 h. The rats were killed and skeletal muscles were isolated rapidly ten minutes after insulin (10 U·kg -1 body weigh) intraperitoneal injection. The PKB expressions were tested with Western blotting. RESULTS: The rats in group HFF developed obvious insulin resistance, their PKB expression of skeletal muscle (OD value 8.24±s 0.11 vs 9.36±0.18, P0.01) decreased significantly compared with normal control group. Rats treated with rosiglitazone in group HFR and normal chow intervention in group HFN improved insulin resiatance obviously. Compared with group HFF, their PKB expression (OD value 8.89±0.08, 8.40±0.09 vs 8.24±0.11, P0.01) increased significantly. CONCLUSION: Development of insulin resistance of rats which fed with high fat diet is obviously associated with suppression of insulin-stimulated PKB expression of skeletal muscle. Rosiglitazone can increase PKB expression of skeleted muscle and partially restore the impaired insulin signal transduction, and further improve insulin resistance. This may be one of the mechanisms which decreases the insulin resistance." @default.
- W2385852945 created "2016-06-24" @default.
- W2385852945 creator A5048924658 @default.
- W2385852945 date "2004-01-01" @default.
- W2385852945 modified "2023-09-23" @default.
- W2385852945 title "Effect of rosiglitazone on protein kinase B expression of insulin resistant rats skeletal muscle" @default.
- W2385852945 hasPublicationYear "2004" @default.
- W2385852945 type Work @default.
- W2385852945 sameAs 2385852945 @default.
- W2385852945 citedByCount "0" @default.
- W2385852945 crossrefType "journal-article" @default.
- W2385852945 hasAuthorship W2385852945A5048924658 @default.
- W2385852945 hasConcept C11960822 @default.
- W2385852945 hasConcept C126322002 @default.
- W2385852945 hasConcept C134018914 @default.
- W2385852945 hasConcept C170493617 @default.
- W2385852945 hasConcept C185592680 @default.
- W2385852945 hasConcept C2777391703 @default.
- W2385852945 hasConcept C2778938600 @default.
- W2385852945 hasConcept C2779306644 @default.
- W2385852945 hasConcept C2779959927 @default.
- W2385852945 hasConcept C2780152017 @default.
- W2385852945 hasConcept C2780159080 @default.
- W2385852945 hasConcept C55493867 @default.
- W2385852945 hasConcept C71924100 @default.
- W2385852945 hasConcept C75217442 @default.
- W2385852945 hasConceptScore W2385852945C11960822 @default.
- W2385852945 hasConceptScore W2385852945C126322002 @default.
- W2385852945 hasConceptScore W2385852945C134018914 @default.
- W2385852945 hasConceptScore W2385852945C170493617 @default.
- W2385852945 hasConceptScore W2385852945C185592680 @default.
- W2385852945 hasConceptScore W2385852945C2777391703 @default.
- W2385852945 hasConceptScore W2385852945C2778938600 @default.
- W2385852945 hasConceptScore W2385852945C2779306644 @default.
- W2385852945 hasConceptScore W2385852945C2779959927 @default.
- W2385852945 hasConceptScore W2385852945C2780152017 @default.
- W2385852945 hasConceptScore W2385852945C2780159080 @default.
- W2385852945 hasConceptScore W2385852945C55493867 @default.
- W2385852945 hasConceptScore W2385852945C71924100 @default.
- W2385852945 hasConceptScore W2385852945C75217442 @default.
- W2385852945 hasLocation W23858529451 @default.
- W2385852945 hasOpenAccess W2385852945 @default.
- W2385852945 hasPrimaryLocation W23858529451 @default.
- W2385852945 hasRelatedWork W1992105136 @default.
- W2385852945 hasRelatedWork W2347714188 @default.
- W2385852945 hasRelatedWork W2350245733 @default.
- W2385852945 hasRelatedWork W2350609979 @default.
- W2385852945 hasRelatedWork W2352886834 @default.
- W2385852945 hasRelatedWork W2353967718 @default.
- W2385852945 hasRelatedWork W2363530860 @default.
- W2385852945 hasRelatedWork W2367438366 @default.
- W2385852945 hasRelatedWork W2373334656 @default.
- W2385852945 hasRelatedWork W2374145908 @default.
- W2385852945 hasRelatedWork W2381054727 @default.
- W2385852945 hasRelatedWork W2381795444 @default.
- W2385852945 hasRelatedWork W2388182976 @default.
- W2385852945 hasRelatedWork W2392020357 @default.
- W2385852945 hasRelatedWork W2393416711 @default.
- W2385852945 hasRelatedWork W2393539142 @default.
- W2385852945 hasRelatedWork W2394092641 @default.
- W2385852945 hasRelatedWork W2590162957 @default.
- W2385852945 hasRelatedWork W3030269341 @default.
- W2385852945 hasRelatedWork W3030901011 @default.
- W2385852945 isParatext "false" @default.
- W2385852945 isRetracted "false" @default.
- W2385852945 magId "2385852945" @default.
- W2385852945 workType "article" @default.