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- W2385865898 abstract "AIM: To investigate the effect of atorvastatin on neointimal hyperplasia of autogenous vein graft in rats.METHODS: The model of autogenous vein graft was prepared by transplanting the external jugular vein into aorta in Wistar rats.The rats were divided into three groups: sham operation group,graft control group and graft experimental group.From three days after transplantation,the rats of autograft experimental group were treated by atorvastatin at a dosage of 5 mg·kg-1·d-1.Four weeks after treatment,venous autografts were removed at autopsy and cut into 4 μm sections.Histopathological examination was carried out to analysis the neointimal hyperplasia of grafted veins.Immunohistochemical stainingwas conducted to evaluate SMα-actin and PCNA expression of neointimal cells in venous autografts.RESULTS: In venous autograft control and experimental groups,SMα-actin-positive smooth muscle cells were proliferated and accumulated excessively in venous autografts,which resulted in significant neointimal formation and vascular lumen narrowing.Neointima quantitative assay revealed that the neointimal hyperplasia of venous autografts was suppressed obviously in graft experimental group,and its neointimal area and NIA/MA ratio of venous autografts were significantly lower than those in graft control group(P0.01).Immunohistochemical assay indicated that the PCNA labeling index of neointimal cells was significantly lower in graft experimental group than that in graft control group(P0.01).CONCLUSION: Atorvastatin significantly inhibits the proliferation of neointimal smooth muscle cells and the development of neointimal hyperplasia of venous autografts in rats.Atorvastatin is a powerful inhibitor of restenosis after vascular reconstructive operation with a potential for therapeutic use." @default.
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- W2385865898 date "2009-01-01" @default.
- W2385865898 modified "2023-09-23" @default.
- W2385865898 title "Effect of atorvastatin on neointimal hyperplasia of venous autografts in rats" @default.
- W2385865898 hasPublicationYear "2009" @default.
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