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- W2385896968 abstract "Objective To study the role of CC16,lung-derived antinflammatory factor,in the acute lung injury(ALI)induced by lipopolysaccharide(LPS)and the effect of recombinant human growth hormone(rhGh)on it.Metholds Sixty-four health Sprague-Dawley rats were randomly divided into rhGh pretreated group(rhGh group) and normal saline pretreated group(NS group).After pretreated by LPS or sterilized NS for consecutive 7 days,the animals in either group were subdivided into LPS injuried subgroup(LPS24 h group)and NS controlled subgroup(LPS0 h group).Five milligram LPS /kg of body weight or equal volume sterilized NS was injected into each rat in LPS 24 h group or LPS 0 h group through thigh vein respectively.Twenty-four hours after LPS or NS injection,the lungs were recovered and histological examinations were carried out in 8 animals in each subgroup.The CC16 contents in bronchoalveolar lavage fluid(BLAF) recovered from another 8 animals in each subgroup were semiquantitively determined by Western blot.Results Significant inflammatory lung injury was observed in 24 hours after LPS injection and the contents of CC16 in BALF were significant lower after the injection of LPS.No significant differences were observed in the contents of CC16 in BALF between the NS and LPS pretreated group before or after the LPS injection.Conclusion The low content of lung-derived CC16 may play an important role in the mechanism of ALI induced by LPS.RhGh pretreatment has no significant effect on the content of CC16 in BALF." @default.
- W2385896968 created "2016-06-24" @default.
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- W2385896968 date "2004-01-01" @default.
- W2385896968 modified "2023-09-25" @default.
- W2385896968 title "The Changes of CC16 in BALF of ALI Rats Induced by LPS and the Effect of RhGh" @default.
- W2385896968 hasPublicationYear "2004" @default.
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