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- W2385921834 abstract "Objective:To investigate the effects of rosiglitazone on vascular restenosis and explore its cellular mechanism. Method:Ninety SD rats were divided into three groups randomly: sham group, angioplasty group and rosiglitazone group. Thoracic aortas were isolated for observation of morphological changes by macroscope and HE stanining method. The protein expressions of matrix metalloproteinase-9(MMP-9) and phosphate extracellular signal-regulated kinase 1/2 (pERK1/2) were measured by immunohistochemical, and the mRNA expressionin of MMP-9 were measured by situ hybridization technique.The level of plasma TXB2 was measured with radioimmunoassay. Result:Compared with the angioplasty group, the intima area was smaller in the rosiglitazone group(P0.05),and the lumen area was larger (P0.05). The protein and mRNA expression of MMP-9 and pERK1/2 were remarkably lower in rosiglitazone group (P0.05). Compared with angioplasty group, the concerntration of plasma TXB2 was remarkably lower in rosiglitazone group. Conclusion:Rosiglitazone may attenuate restenodsis by suppressing expression of MMP-9 through pERK1/2 signal transduction pathway, and decreasing the release of TXA2 in aorta-injured rats." @default.
- W2385921834 created "2016-06-24" @default.
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- W2385921834 date "2006-01-01" @default.
- W2385921834 modified "2023-09-26" @default.
- W2385921834 title "Effects of rosiglitazone on vascular restenosis and expression of matrix metalloproteinase-9 in aorta-injured rats" @default.
- W2385921834 hasPublicationYear "2006" @default.
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