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- W2385936183 abstract "HIV-1 integrase catalyzes the integration of proviral DNA into the genome of the host cell,an essential step for viral replication,thus inhibition of integrase catalytic activity represents a rational strategy for the treatment of HIV-1 infection.At present,a lot of HIV-1 integrase inhibitors have been designed and synthesized,and some of them are studied currently in clinical trials.In a view of chemical structure,most of the HIV-1 integrase inhibitors reported belong to the class of diketo acids or their bioisosters.Recent advances on diketo acid HIV-1 integrase inhibitors are reviewed in this paper." @default.
- W2385936183 created "2016-06-24" @default.
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- W2385936183 date "2009-01-01" @default.
- W2385936183 modified "2023-09-26" @default.
- W2385936183 title "Progress on diketo acid HIV-1 integrase inhibitors" @default.
- W2385936183 hasPublicationYear "2009" @default.
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