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- W2385945359 abstract "Objective:To investigate the effects of early growth respons gene-1(Egr-1) on the proliferation,apoptosis and phenotype transformation of vascular smooth muscle cell(VSMC).Methods:The VSMCs of the rat thoracic aorta were subcultured by the method of adherence.The third to eighth generation of cells was selected for the experiment.The experiment consisted of the control group and Egr-1 group.We applied the MTT method respectively to study the effects on the proliferation of VSMC by Egr-1 at different concentrations and the different effect time.The method of transmission electron microscope and TUNEL were used to study the effect of Egr-1 with different effect time on phenotype transformation and apoptosis of VSMC.Results:There were significant differences in OD values tested by MTT assay at different concentrations of Egr-1 group compared with the control group,(P0.05).Egr-1 showed the most significant effect on promoting VSMC proliferation when the concentration was at 40μg/mL.Atr the optimal concentration(40μg/mL),the peak of VSMC proliferation promoted by Egr-1 was at 24h.The most obvious action of inhibiting VSMC apoptosis by Egr-1 was at 12h.The effect of Egr-1 on VSMC apoptosis was negatively correlated within a certain time.When it was at 24h,Egr-1 played the most significant role in promoting converting to synthetic phenotype of VSMC.Conclusion:Promotion proliferation action on VSMC by Egr-1 is positively correlated with the concentration and action time within a certain range.To some extent,Egr-1 has an effect on inhibiting VSMC apoptosis and promoting VSMC converting from contractile type to synthetic type." @default.
- W2385945359 created "2016-06-24" @default.
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- W2385945359 date "2010-01-01" @default.
- W2385945359 modified "2023-09-26" @default.
- W2385945359 title "Effects of early growth response gene-1 on proliferation,apoptosis and phenotype transformation of vascular smooth muscle cell" @default.
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