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- W2385958202 abstract "Objective To study the effect of fluoride on the expressions of collagen type I (Col I ) and collagen type III (Col III ) in the myocardium of rats. Methods The rat model was established by administration of different concentration of sodium fluoride. The myocardium of rats were stained by picrosirium red, observed by polarization microscopy, analyzed by image analysis system. The expressions of Col I and Col III in myocardium of rats were determined by immunohistochemistry method. Results The percentages of Col I and Col III area in the myocardium of rats treated with different concentration of sodium fluoride were a little higher than those of control group. No significant difference was seen among different groups of the expressions of Col I and Col III (P0. 05). The expressions of Col I and Col III protein were ranged between 0 - 10%. There was no significant difference among different groups either (P0. 05). Conclusion Chronic fluorosis has no obvious effect on myocardial collagen metabolism of rats and myocardial collagen is not likely the main target of fluoride." @default.
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- W2385958202 date "2006-01-01" @default.
- W2385958202 modified "2023-09-25" @default.
- W2385958202 title "Effect of chronic fluorosis on myoardial collagen metabolism in rats" @default.
- W2385958202 hasPublicationYear "2006" @default.
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