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- W2385963319 abstract "Objective: To investigate the effects of docosahexaenoic acid(DHA) on action potentials(AP) and sodium channel current(INa) in rat ventricular myocytes.And evaluate the anti-arrhythmia mechanisms of DHA.Methods: Rat ventricular myocytes were isolated by enzyme digestion method.AP and INa of individual ventricular myocytes were recorded by patch-clamp technique at room temperature.Effects of DHA on AP and sodium channels were observed when it was applied at 0 μmol/L,20 μmol/L,40 μmol/L,60 μmol/L,80 μmol/L,100 μmol/L and 120 μmol/L respectively.Results: ① APD25,APD50 and APD90 are gradually prolonged with augmentation of DHA(P0.05,n=20),but Vmax,APA and OS were not significant(P0.05,n =20).② INa were gradually blocked,I-V curves were upward,stably inactivated curves were shifted to the left,and recovered time from inactivation was prolonged(P0.05,n=20),and stably activated curves were no remarkable significance(P0.05,n=20).INa was blocked to(1.51±1.32)%,(21.13±4.62)%,(51.61±5.73)%,(67.62±6.52)%,(73.49±7.59)% and (79.95±7.62)% under manding potential equal to-30 mV(P0.05,n=20),and 50% inhibition concentration(EC50) of DHA was(47.91±1.57) μmol/L.Conclusion: The blocked effects of DHA on APD and INa are beneficial to prevent arrhythmia." @default.
- W2385963319 created "2016-06-24" @default.
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- W2385963319 date "2010-01-01" @default.
- W2385963319 modified "2023-09-27" @default.
- W2385963319 title "Effects of docosahexaenoic acid on action potentials and sodium channel current in rat ventricular myocytes" @default.
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