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- W2385973354 abstract "Objective To compare the differences of ventricular arrhythmia occurrences among different models of acute myocardial infarction(MI).Methods Forty-five pigs were randomly divided into 3 groups: Sham operation group(Sham group,n=5),left anterior descending(LAD) artery ligation-induced MI model(ligation group,n=17) and balloon catheter based LAD occlusion-induced MI model(occlusion group,n=23).The occurrences of ventricular arrhythmias were recorded by ECG monitoring after 90 minutes of ligation or occlusion.8 weeks later,2,3,5-triphenyl tetrazolium chloride(TTC) staining,HE staining were used to examine whether the infarction model was successful.Results The immediate survival rate of occlusion group was lower(60.87% vs 94.12%,P=0.042).There were no differences between the two different MI models in regards to the incidence of premature ventricular contractions and ventricular tachycardia(91.30% vs 70.59%,30.43% vs 29.41%;both P0.05) during the operation procedure,but the incidence of ventricular fibrillation was significantly higher in occlusion group(69.57% vs 5.88%,P0.001).After 8 weeks,TTC and HE staining showed that there was no significant difference in the model success rate(68.75% vs 92.86%,P = 0.234),but the infarct area was higher in the occlusion group.Conclusions Compared with conventional ligation methods,LAD occlusion methods can lead to a large area of MI and the higher incidence of ventricular arrhythmias." @default.
- W2385973354 created "2016-06-24" @default.
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- W2385973354 date "2012-01-01" @default.
- W2385973354 modified "2023-09-25" @default.
- W2385973354 title "The occurrences of ventricular arrhythmia after acute myocardial infarction in a porcine model: comparison between ligation and occlusion" @default.
- W2385973354 hasPublicationYear "2012" @default.
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