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- W2385990807 abstract "Objective To study the relationship between loss of heterozygosity(LOH) and microsatellite instability(MI) on chromosome 1, 10, 14 and 22 in meningiomas and the tumor progression, flow cytometry (FCM) analysis and tumor recurrence. Methods The DNA of the tumor tissues and venous blood of 39 patients with meningiomas were extracted. LOH and MI on chromosome 1p, 10q, 14q and 22q were detected by the method of PCR amplification, the relationships between LOH and MI and the pathological subtypes, histological grading, DI, DNA polidy and tumor recurrence were analysed. Results The LOH(+) rate of D1S188, D10S187, D14S43 and D22S1 in the anaplastic meningiomas were higher than that in the benign tumors significantly (P0 05～0 005); LOH(+) rate of D14S43 were higher than that in the atypical ones(P=0 015). DI in the above four loci LOH(+) group were more than that in the corresponding loci LOH(-) group respectively. The rate of hyperdiploidy in D1S188 LOH(+), D14S187 LOH(+) and D22S1 LOH(+) groups were higher than those LOH(-) correponding groups. Among the in 6 cases recurrent tumors group, 5 were LOH(+). The rate of D1S188 LOH(+) in the recurrent tumor group were more than that in the primary tumor group (P0 05). Between any two groups, no significant difference of MI were found.Conclusions LOH on D1S188, D10S187,D14S43 and D22S1 in meningiomas had the close relationships with the oncogenesis and the tumor progression." @default.
- W2385990807 created "2016-06-24" @default.
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- W2385990807 date "2001-01-01" @default.
- W2385990807 modified "2023-09-26" @default.
- W2385990807 title "Loss of heterozygosity and microsatellite instability on chromosome 1, 10, 14 and 22 in meningiomas and correlated factors" @default.
- W2385990807 hasPublicationYear "2001" @default.
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