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- W2385993357 abstract "Objective:To study the pharmacokinetics of acetaminophen succinate in healthy rabbit after intramuscular injection.Methods: RP-HPLC was used to determine the acetaminophen concentration of 6 adult healthy rabbits at different time after injecting acetaminophen succinate. Then the pharmacokinetic parameters were disposed by DAS 2.0 pharmacokinetic software.Results:The concentration-time curve of acetaminophen succinate in rabbit was single compartment model(weight coefficient=1/C2). The main pharmacokinetic parameters was:Tmax=0.25h,Cmax=95.44mg/L,t1/2(α)=0.73h,t1/2(β)=2.70h,AUC= 82.44 mg/L*h,Vd=45.65L/kg.Conclusions:Compared with muscular injection of acetaminophen,the Tmax and t1/2(β) of muscular injection of acetaminophen succinate shorten obviously,which indicates that acetaminophen succinate onset quickly and remove rapidly in vivo." @default.
- W2385993357 created "2016-06-24" @default.
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- W2385993357 date "2014-01-01" @default.
- W2385993357 modified "2023-09-23" @default.
- W2385993357 title "STUDY ON THE PHARMACOKINETICS OF ACETAMINOPHEN SUCCINATE IN RABBIT" @default.
- W2385993357 hasPublicationYear "2014" @default.
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