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- W2386011296 abstract "Objective: The metabolic kinetics of two metabolites from tertiary butylhydroquinone,tertiary butylhydroquinone-sulfate and tertiary butylhydroquinone-glucuronide were investigated in rats.Methods: The concentrations of the metabolites in the serum of rats after oral exposure of tertiary butylhydroquinone were semi-quantitatively analyzed by liquid chromatography-mass spectrometry(LC-MS).Compartment model and metabolic kinetic parameters were evaluated by practical pharmacokinetic program.Results: The serum concentration-time profiles of two metabolites could be fitted with a two-compartment model and obeyed first-order kinetics.Conclusion: After oral administration of tertiary butylhydroquinone,the peak time of tertiary butylhydroquinone-sulfate and tertiary butylhydroquinone-glucuronide in the serum of rats were 0.17-0.61 h and 0.23-0.74 h,the distribution half-lives 0.32-1.11 h and 0.2-2.60 h,and the elimination half-lives 11.75-24.54 h and 24.42-55.78 h,respectively.The concentrations of two metabolites in the serum of male rats were higher than those in female rats.The exposure of two metabolites increased in a less-than-dose-proportional manner.Moreover,the metabolism of tertiary butylhydroquinone in rats reached saturation with increasing dose." @default.
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- W2386011296 date "2012-01-01" @default.
- W2386011296 modified "2023-09-22" @default.
- W2386011296 title "Metabolic Kinetics of Two Metabolites from Tertiary Butylhydroquinone" @default.
- W2386011296 hasPublicationYear "2012" @default.
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