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- W2386017072 abstract "Objective To observe the biological performance of the low elastic modulus expandable screw in osteoporotic sheep in vivo and to find out whether the stability of the screw can be improved.Methods Four adult female sheep were ovariectomized.After 12 months,the bone mineral density of the lumber vertebra was determined using dual energy X-ray absorptiometry to confirm the establishment of the osteoporosis model.Bilateral pedicles of the lumbar vertebrae(L1-L5) were random fixed with two different elastic modulus expendable screws,low elastic module expandable screws(42GPa) for the experiment group and ordinary expandable screws(110GPa) for the control group.All the animals were sacrificed 3 months after the implantation.Maximal force testing,micro-CT measurement,and histology analysis were performed.Results BMD of the lumbar vertebrae of the sheep decreased significantly 1 year after ovariectomy(P0.05).After 3 months implantation,the maximal axial pull-out strength in experimental group was significantly enhanced compared to that in the control group(P0.05).Micro-CT analysis showed that BV/TV,Tb.Th and Tb.Sp improved in experimental group compare to those in the control group(P0.05),but no difference in Tb.N.between the two groups(P0.05).Histological observation showed that newly formed bone around the screws was more in the experimental group than in the control group.Meanwhile more tight contact and less fibrous connective tissue were observed on the screw-bone interface in the experimental group.Conclusion The low elastic modulus expandable screws can further improve the biomechanical fixation strength in osteoporotic sheep and reduce the failure of the screw fixation,through reduction of the difference of elastic modulus between the screws and the surrounding bone tissue." @default.
- W2386017072 created "2016-06-24" @default.
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- W2386017072 date "2011-01-01" @default.
- W2386017072 modified "2023-09-23" @default.
- W2386017072 title "Study of low elastic modulus expandable screws in osteoporotic sheep in vivo" @default.
- W2386017072 hasPublicationYear "2011" @default.
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