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- W2386018807 abstract "Aim at evaluate the anticancer activity of FB2,a Src kinase inhibitor,on prostate cancer.Animal experiments are used to determine the antitumor activity of FB2 on PC-3 xenograft tumor growth in vivo.MTT assays,colony formation and adhesion assays are utilized to assess impact of FB2 on the cell proliferation and cell adhesion.Flow cytometry is used to analysis cell cycle distribution.Western blot is used to analysis the level of phosphorylation of Src at Tyr 416 and Src.FB2 had significant antitumor activity on PC-3 xenograft in nude mice and inhibited the cell proliferation.FB2 inhibited cell adhesion and caused cell cycle arrest in G1 phase.FB2 inhibited Src phosphorylation at Tyr 416.FB2 had inhibitory effects on prostate cancer in vitro and in vivo through blocking Src phosphorylation at Tyr 416." @default.
- W2386018807 created "2016-06-24" @default.
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- W2386018807 date "2009-01-01" @default.
- W2386018807 modified "2023-09-26" @default.
- W2386018807 title "Anticancer activity of FB2,a Src kinase inhibitor,on prostate cancer" @default.
- W2386018807 hasPublicationYear "2009" @default.
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