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- W2386042390 abstract "Objective To investigate the relationship between genetic polymorphisms of cytochrome P450 2E1 (CYP2E1) and the susceptibility to gastric carcinoma,and to study the action between environmental and genetic factors in the development of gastric carcinoma.Methods The Rsa I polymophism of CYP2E1 of 48 patients with gastric cancer and 48 controls were detected by PCR-RFLP.Related information of environmental factors were collected and analyzed by using the multiple-variable Logistic regression models.Results The frequency distribution of 3 genotype of CYP2E1 were 68.8%,29.2% and 2.1% in cases and 45.83%,47.92% and 6.25% in controls (χ2=5.389,P=0.068).The frequencies of the allele c1 and c2 CYP2E1 were 83.3%,16.7% respectively in cases and 69.8%,30.2% respectively in controls.Gastric cases were more likely to carry allele c1 than controls.(χ2=5.241,P0.05).Multi-variable stepwise logistic regression showed that high intake of salt,sausage and fried food were the risk factors for gastric cancer,while consumption of tea was the protective factors for gastric cancer.Conclusion Genetic polymorphism of cytochrome P4502 E1 and some environmental factors were significantly related with the risk of gastric cancer." @default.
- W2386042390 created "2016-06-24" @default.
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- W2386042390 date "2005-01-01" @default.
- W2386042390 modified "2023-09-23" @default.
- W2386042390 title "Effects of genetic polymorphism of cytochrome P4502 E1 on susceptibility to gastric cancer" @default.
- W2386042390 hasPublicationYear "2005" @default.
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