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- W2386045149 abstract "Aim To study the effects of berberine on oxidative stress and endoplasmic reticulum stress of insulin resistant rats,and to explore its possible molecular mechanism.Methods Seventy male wistar rats were fed with a high-fat and high-caloric diet to establish insulin resistance model.After 8 weeks' feeding,serum fasting blood glucose(FBG),fasting insulin(Fins),insulin sensitivity index(ISI) were determined.Forty-two insulin resistant rats were successfully induced and were randomly divided into model,berberine and alpha-lipoic acid(ALA) groups,with 14 animals in each group.Another 12 normal rats were used as control group.After administration with corresponding drugs for 4 weeks,the rats were sacrificed and serum malonaldehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) were determined.The GRP78 mRNA expression in liver was determined by reverse-transcription polymerase chain reaction(RT-PCR).Western blot analysis was employed to detect liver Phospho-c-Jun /JNK protein expression.Results Compared with control group,model group showed higher MDA level while significantly decreased SOD and GSH-Px activity(P0.05).In berberine and ALA groups,SOD and GSH-Px were elevated drastically compared to those of model group(P0.01 or P0.05),while MDA level was significantly decreased compared with that of model group.Protein expression of Phospho-c-Jun/JNK in model group was significantly higher than that in control group while its expression in berberine group was significantly decreased than that in model group(P0.01).The GRP78/Bip mRNA was significantly increased in model group(P0.05),while obviously decreased in berberine and ALA groups compared with normal control.Conclusion Berberine could improve insulin resistance,which might be correlated with its anti-oxidative effect and its preventive effect on endoplasmic reticulum stress." @default.
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- W2386045149 date "2008-01-01" @default.
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- W2386045149 title "Effects of berberine on oxidative stress and endoplasmic reticulum stress in insulin resistance rats" @default.
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