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- W2386069844 abstract "Objective To investigate the effects of histone deacetylase inhibitor SAHA combined with chemotherapy on the proliferation of stomach cancer cells in rats.Methods Rat models with transplanted stomach cancer cell hBGC-823 were constructed and randomized into 6 groups,rats in each group received corresponding treatments.Serum levels of cholesterol,glutamic-pyruvic transaminase,bilirubin,urea nitrogen,and creatinine;the counting of white blood cells,red blood cells,and platelets;body weight and wet weight of tumor were recorded,then the tumor growth inhibition rate and tumor volume were analyzed.Results Tumor growth inhibition rates were increased and tumor volumes were decreased in the other 5 groups than those in control group(P 0.05),especially in oxaliplatin plus SAHA group(P 0.05).The increase of body weight and serum levels of glutamic-pyruvic transaminase and bilirubin,and the decrease of white blood cell counting were observed in the groups containing oxaliplatin or 5-FU(P 0.05),but there was no statistical difference of these 4 kinds of index between oxaliplatin or 5-FU alone groups and SAHA combined with oxaliplatin or 5-FU groups(P 0.05).Conclusions In nude rat models with stomach cancer,SAHA combined with chemotherapy(oxaliplatin or 5-FU) can lead to synergistic effects but little side effects." @default.
- W2386069844 created "2016-06-24" @default.
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- W2386069844 date "2012-01-01" @default.
- W2386069844 modified "2023-09-24" @default.
- W2386069844 title "Effects of histone deacetylase inhibitor SAHA combined with chemotherapy on the proliferation of stomach cancer cells in rats" @default.
- W2386069844 hasPublicationYear "2012" @default.
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