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- W2386077024 abstract "Objective To investigate the role of B7-CD28/CTLA-4(CD152),co-stimulatory molecules of T lymphocytes in the pathagenesis of recurrent genital herpes(RGH).Methods Flow cytometry was utilized to detect the expression levels of CD80(B7-1)/86(B7-2) in peripheral blood lymphocytes and of CD28/CD152 in CD4+/CD8+T lymphocytes from 50 patients with RGH and 20 healthy volunteers as controls.Results The frequencies of CD80,CD86 lymphocytes were significantly higher in the recurrent group than those in the control group(P0.05).The frequencies of CD8+/CD28 cells were significantly higher in the control group than those in the recurrent group(P0.05).The frequencies of CD4+/CD152,CD8+/CD152 cells were significantly higher in the recurrent group than those in the control group(P0.05).Conclusion Herpes simplex virus infection may result in the activation and proliteration of CD80,CD86,CD28 and CD152,expression of high level negative costimulatory molecules and secretion of suppressive cytokines,which may lead to the inhibition of antiviral immune responses via multiple mechanisms." @default.
- W2386077024 created "2016-06-24" @default.
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- W2386077024 date "2012-01-01" @default.
- W2386077024 modified "2023-09-26" @default.
- W2386077024 title "Analysis of costimulatory molecules B7-1 and B7-2 in peripheral blood lymphocytes of patients with recurrent genital herpes" @default.
- W2386077024 hasPublicationYear "2012" @default.
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