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- W2386078633 abstract "OBJECTIVE:To investigate the effects of atorvastatin on the expression of Connexin 43 and Connexin 40 in human umbilical vein endothelial cells(HUVECs) induced by oxidized low-density lipoprotein(ox-LDL).METHODS:Cultured HUVECs were divided into control group,ox-LDL group,positive control group and atorvastatin groups.Except for control group,the other groups were treated with culture medium,culture medium(added 50 μmol/L heptanol),culture medium(added 0.01,0.1,1.0 and 10 μmol/L atorvastatin)for 30 min,respectively,and then incubated with 50 mg/L ox-LDL for 24 h.NO concentration was determined by nitrate reductase method,and location expression of Connexin 43 was observed using immunocytochemistry,and quantitative expressions of Connexin 43 and Connexin 40 were measured by Western blotting.RESULTS:Compared with control group,NO concentration of other groups decreased significantly while expression of Connexin 43 and Connexin 40 increased significantly(P0.01).The location expression of Connexin 43 was found in those groups except for positive control group and 10 μmol/L atorvastatin group.Compared with ox-LDL group,the NO concentration of positive control group increased significantly while the quantitative expression of Connexin 43 and Connexin 40 decreased significantly(P0.05 or P0.01);NO concentration of atorvastatin groups increased and the quantitative expression of Connexin 43 and Connexin 40 decreased gradually in dose-dependent manner(P0.05 or P0.01).Compared with positive control group,the above index of 10 μmol/L atorvastatin group had no statistical difference(P0.05).CONCLUSIONS:Atorvastatin can obviously inhibit the protein expression of Connexin 43 and Connexin 40 in HUVECs injured by ox-LDL in dose-dependant manner and protect the gap junction of HUVECs to play lipid regulation and anti-atherosclerosis function of statins." @default.
- W2386078633 created "2016-06-24" @default.
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- W2386078633 date "2013-01-01" @default.
- W2386078633 modified "2023-09-25" @default.
- W2386078633 title "Effects of Atorvastatin on Gap Junction of Human Umbilical Vein Endothelial Cells Induced by ox-LDL" @default.
- W2386078633 hasPublicationYear "2013" @default.
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