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- W2386086723 abstract "AIM To compare two methods of quantitating spontaneous pain related responses on evaluating the analgesic effect of morphine. METHODS After subcutaneous injection of bee venom into the plantar of one hindpaw in rats, the nociceptive responses were evaluated by two different methods: by counting the number of flinching reflex and by the four grade weight scoring. RESULTS The suppressive effect of pretreatment with morphine i.v. was found. Pretreatment with 0.015, 0.15, 0.3, 0.47, 1.5, 3.0 mg·kg -1 morpine i.v. significantly produced a dose dependent suppression of the bee venom induced spontaneous pain related responses ( P 0.05). The inhibitory rates were 17, 39, 48, 52, 62 and 89 per cent. The ED 50 of morphine was 0.29 mg·kg -1 . Pretreatment with 1.5 mg·kg -1 morphine i.v. produced significant suppression on the bee venom induced lifting/licking nociceptive score. CONCLUSION Pretreatment with morphine i.v. can produce a dose dependent suppression on the bee venom induced spontaneous flinching reflex. In the bee venom test, the spontaneous flinching reflex as quantitative measure of spontaneous pain related responses is more simple, stable and objective than lifting/licking nociceptive score." @default.
- W2386086723 created "2016-06-24" @default.
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- W2386086723 date "2001-01-01" @default.
- W2386086723 modified "2023-09-25" @default.
- W2386086723 title "Two methods of quantitating the bee venom-induced spontaneous pain-related responses and the analgesic effect of morphine" @default.
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