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- W2386095283 abstract "To study the effects of medroxyprogesterone acetate (MPA) and conjugated estrogen (CE) plus MPA replacement on menopausal symptoms, serum lipid profile, bone mineral surface density (BMSD) and biochemical bone markers in postmenopausal women. 88 naturally menopausal healthy women were randomly divided into 2 groups: group A (n=48): MPA 10 mg daily; group B (n=40), CE 0 625 mg plus MPA 2 mg daily; Both treatments lasted for 6 months. The menopausal symptoms, serum lipids and lipoproteins, lumbar spine BMSD, serum osteocalcin (BGP) and urinary pyridinoline concentrations were evaluated at baseline and 6 months after treatment. ① The scores of menopausal symptoms in both groups were reduced after treatment (P0 01); ② The BMSD of L 2～4 in both groups slightly increased; ③ There was no obvious change in BGP concentration (P0 05), but significant reduction of urinary pyridinoline/creatinine ratio(Pyr/Cr) in group B(P0 05 )was found. On the contrary, there was obvious increase in BGP concentration(P0 05), but no apparent change in urinary Pyr/Cr in group A (P0 05). ④ MPA had no remarkable effects on both lipid and lipoprotein(P0 05), but in group B, serum TG, HDL C and ApoA Levels significantly increased(P0 05), while TC and LDL C levels significantly decreased(P0 05), ApoB changed little(P0 05) after treatment. [Conclusion] ① Both MPA and CE plus MPA replacement can relieve menopausal symptoms; ② Both MPA and CE plus MPA replacement can slightly increase BMSD; ③CE can inhibit bone resorption, and MPA alone can promote bone formation; ④ MPA has no effect on lipids metabolism, whereas CE plus MPA can improve the profile of lipids composition, which might be beneficial for the cardiovascular system." @default.
- W2386095283 created "2016-06-24" @default.
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- W2386095283 date "2002-01-01" @default.
- W2386095283 modified "2023-09-24" @default.
- W2386095283 title "Effects of Estrogen and Progestin replacement on Menopausal Symptoms, Lipid Profile and Biochemical Bone Markers in Postmenopausal Women" @default.
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