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- W2386097498 abstract "Objective To evaluate the safety and efficacy of three different concentrations of sufentanil for post-operative analgesia after craniotomy surgery.Methods Sixty ASA class Ⅰ or Ⅱ neurogenous patients (32 males and 28 females) aged 21 to 60 years old were randomly assigned to receive PCIA with ondansetron 16 mg and sufentanil 2 μg/kg(group A,n=20),3 μg/kg (group B, n=20) or 4 μg/kg (group C,n=20) diluted with normal saline 100 ml.VASt and VASm which were used to assess analgesia at rest and during movement at 1,2,18,24 and 48 h after surgery.The observer's assessment of alertness/sedation (OAA/S) scale,total bolus doses,PCIA button pressing times,vital signs including SBP,DBP,HR,RR,SpO_2 and side effects (respiratory depression, nausea,vomiting and pruritus) were recorded.Results During the 24 to 48 hours after craniotomy surgery,the VASr and VASm scores in group C were significantly lower than those in group A (P 0.05 or P0.01).The vital signs were stable and the incidence of side-effects was not significantly different.Conclusion Post-operative analgesia with these three concentrations of sufentanil are effective and safe,and with 4 μg/kg sufentail in 100 ml normal saline analgesia is better." @default.
- W2386097498 created "2016-06-24" @default.
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- W2386097498 date "2008-01-01" @default.
- W2386097498 modified "2023-09-28" @default.
- W2386097498 title "Application of sufentanil for post-operative analgesia in patients underwent craniotomy surgery" @default.
- W2386097498 hasPublicationYear "2008" @default.
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