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- W2386098162 abstract "Objective Recent studies have found that estrogen receptor estrogen receptor( ER) activation by ligand binding results in events that suggest a non-genomic effect,and estrogen can affect the insulin-like growth factor-Ⅰ( IGF-Ⅰ) system. The aim of this study is to study interaction between insulin-like growth factor receptor( IGF-IR) and ER induced by estradiol and IGF-Ⅰ.Methods Two cell lines,MCF-7 and NWTB3,were used. MCF-7 cells with ER and IGF-IR positive were transfected with empty vector( NEO) or anti-sense IGF-IR( SX13). IGF-IR generated NWTB3 cells with negative ER were transfected with ER. Immunoprecipitation was used to study the interaction between ER and IGF-IR.The downstream signaling activation of IGF-IR was measured by immunoblotting. GFP-ER localization in cells was determined using live microscopy. Results IGF-IR on the cell membrane decreased 50%in MCF-7 cells after transfected with IGF-IR anti sense cDNA. In NEO cells,estradiol and IGF-Ⅰinduced a rapid combination of ER and IGFIR,and the interaction was abrogated in SX13 cells. Following transfection of NWTB3 cells( overexpressing the IGF-IR) with ER,the interaction between ER and-IGF-IR was induced within 15 minutes by estradiol and IGF-Ⅰ. Conclusion The interaction of the ER and IGF-IR may play an important role in the non-genomic effects of ER." @default.
- W2386098162 created "2016-06-24" @default.
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- W2386098162 date "2013-01-01" @default.
- W2386098162 modified "2023-09-26" @default.
- W2386098162 title "Interaction between insulin-like growth factors I receptor and estrogen receptor induced by estradiol and insulin-like growth factors I" @default.
- W2386098162 hasPublicationYear "2013" @default.
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