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- W2386099169 abstract "OBJECTIVE To investigate the oxidative damage following brain ischemia,and the effect of edaravone on rats suffering vascular dementia (VD).METHODS A chronic ischemia model was made through permanent bilateral carotid arteries occlusion.Fifteen days later,rats in edaravone-treated group were injected with 3 mg·kg-1 edaravone subcutaneously once a day in another 45 days.Then,the hippocampuses were prepared for measure of SOD and MDA (biochemical methods),morphological observation (HE staining),test of bax mRNA (reverse-transcriptase PCR) and cognitive assessment (Y-type maze).RESULTS In the hippocampus,MDA was increased,SOD was decreased,bax mRNA was upregulated,percentage of TUNEL (+) cells in CA1 was increased,and cognitive damage was enhanced by the ischemia.But edaravone treatment partly retrieved all of those damages significantly (P0.01).CONCLUSION Oxidative stress exists persistently after ischemia,which maybe an important cause to the dementia;edaravone can improve cognitive functions of VD rats,partly through suppressing oxidative damage and delayed neuronal death in hippocampus." @default.
- W2386099169 created "2016-06-24" @default.
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- W2386099169 date "2009-01-01" @default.
- W2386099169 modified "2023-09-24" @default.
- W2386099169 title "Effect of edaravone on oxidative stress and neuronal death after vascular dementia" @default.
- W2386099169 hasPublicationYear "2009" @default.
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