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- W2386145674 abstract "To investigate the effect of resistin on human umbilical vein endothelial cells(HUVEC),and to explore the role and mechanisms of resistin on atherosclerosis.【Methods】 Human umbilical vein endothelial cells were incubated with recombinant human resistin(0,50,and 100 ng/ml) for 24 hours.ICAM-1,VCAM-1,and ROS were assessed using flow cytometry.ET-1,eNOS,and iNOS mRNA expression were measured by semi-quantitative RT-PCR.【Results】 Incubation of HUVEC with resistin resulted in an increase in ICAM-1 and ET-1 mRNA expression.But resistin had no effect on VCAM-1 expression and ROS release.eNOS and iNOS mRNA expression were not altered by resistin stimulation.【Conclusion】 Adipokine resistin exerts direct effects to promote HUVEC dysfunction by promoting ICAM-1 and ET-1 expression.These data suggest that adipocyte-endothelium cross talk might play an important role in pathogenesis of cardiovascular disease in diabetes." @default.
- W2386145674 created "2016-06-24" @default.
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- W2386145674 date "2006-01-01" @default.
- W2386145674 modified "2023-09-24" @default.
- W2386145674 title "Dysfunction of Human Umbilical Vein Endothelial Cell Induced by Resistin" @default.
- W2386145674 hasPublicationYear "2006" @default.
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