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- W2386155172 abstract "Objective To investigate the trends of peripheral blood leucocyte counts and MMP-9/TIMP-1 ratio in acute experimental subarachnoid hemorrhage model in rats and their relationship with early brain injury.Methods A rat single cisterna magna injection model was used.Leukocytes were counted by blood counting chamber,and MMP-9 and TIMP-1 were measured by ELISA.The dry-wet weight method was used to measure brain water content.The inside diameter was measured on an HE stained basilar artery.Results The brain water content increased significantly at 6 h after subarachnoid hemorrhage and peaked at 24 h,so did the leukocyte count as well as MMP-9 and TIMP-1 contents.Both the leukocyte count and MMP-9/TIMP-1 ratio were related to early brain injury after subarachnoid hemorrhage.Conclusion The leukocyte count and MMP-9/TIMP-1 ratio increase significantly in the early stage of subarachnoid hemorrhage and return to normal after 72 h.The trend is related to early brain injury after subarachnoid hemorrhage.The MMP-9/TIMP-1 ratio may be used as a predictor of the appearance of early brain injury." @default.
- W2386155172 created "2016-06-24" @default.
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- W2386155172 date "2013-01-01" @default.
- W2386155172 modified "2023-09-26" @default.
- W2386155172 title "The trends of peripheral blood leucocyte counts and MMP-9/TIMP-1 ratio in acute experimental subarachnoid hemorrhage model in rats and their relationship with early brain injury" @default.
- W2386155172 hasPublicationYear "2013" @default.
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