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- W2386155280 abstract "In recent years, the most popular method of linkage analysis and association analysis may be the Transmission / Disequilibrium test (TDT). It is crucial to evaluate the power and the sample size of TDT. Many papers have discussed this subject matter. But, previous approaches are neither accurate nor general. Generally they made a simple assumption that the family structure is unitary with either a single affected offsp0rong (SAO) or affected sib pairs (ASP) or discordant sib pair (DSP), except for those by Chen and Deng. But Chen and Deng did not consider the proportion of different familial structures. Here, employing a computer program developed by Chen and Deng: TDT power calculator (PC) , we investigate the effect of families with different family structures of ASO, ASP and DSP on power of TDT under four model of inheritance (multiplicative, recessive, additive, dominant), from three aspects (1) different proportion of different family structures, (2) different recombination between marker locus and disease-susceptibility locus (DSL), (3) different disease status of parents. We find that, as expected, the sample size of TDT increase with the proportion of SAO or DSP increasing and with the recombination approaching to 1/2. Investigation is of practical application. Because, in practice, families with different structures can be recruited much more. Considering saving time-consuming and financial-consuming, how to plan the proportions of different family structures is important." @default.
- W2386155280 created "2016-06-24" @default.
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- W2386155280 date "2003-01-01" @default.
- W2386155280 modified "2023-09-23" @default.
- W2386155280 title "Power of Transmission/Disequilibrium Test with Different Family Structures" @default.
- W2386155280 hasPublicationYear "2003" @default.
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