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- W2386166685 abstract "Objective: To evaluate the uses and procedures of therapeutic drug monitoring in clinical treatments.Methods: The development history of therapeutic drug monitoring in psychiatrics was reviewed,and four representative cases were analyzed in conjunction with clinical experiences.These cases included concentration rebounding after chlorpromazine overdose,and the treatment was assessed through monitoring drug elimination process.The enzyme activity and metabolic types of CYP2D6 were judged to facilitate individualized medication based on the concentrations of risperidone and 9-OH risperiodne.The impropriety of the prescription was analyzed by determination of concentrations in a patient taking nine therapeutic drugs,who recovered from abnormality after taking single medicine.High-level blood concentration was intensively monitored for controlling concentration variations in patients taking clozapine.Results: Therapeutic drug monitoring could be used in the following situations: monitoring of drug elimination process in overdosed patients,guiding individualized medication through multi-drug concentration monitoring,analysis of the rationale of multi-drug combination,and elucidating abnormal results.Conclusion: Individualized medication can only be achieved on account of an overall judgment involving therapeutic drug monitoring results,patient conditions and clinical efficacy." @default.
- W2386166685 created "2016-06-24" @default.
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- W2386166685 date "2011-01-01" @default.
- W2386166685 modified "2023-09-23" @default.
- W2386166685 title "Therapeutic drug monitoring of psychotropic drugs:a retrospective analysis of four cases" @default.
- W2386166685 hasPublicationYear "2011" @default.
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