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- W2386179670 abstract "OBJECTIVE To establish an HPLC method for determination of ibudilast in human plasma.METHODS Chromatographic conditions included YWG-C_ 18 column, methanol- 0.05 mol·L -1 KH_2PO_4(65:35, pH was adjusted to 3.5 with H_3PO_4) as mobile phase, the UV detection wavelength was 225 nm, the flow rate was 1.0 mL·min -1 and cinnarizine was used as the internal standard.RESULTS The standard curve of ibudilast showed good linearity in the concentration range of 2～120 μg·L -1 ( r = 0.9956 ), the limit of detection was 2 μg·L -1 , the average recovery was 100.2% with RSD of 4.7% ( n =5).CONCLUSIONS The method was found to be simple, sensitive and accurate, it could be used for determining the concentration of ibudilast in human plasma for the research of clinical pharmacokinetics." @default.
- W2386179670 created "2016-06-24" @default.
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- W2386179670 date "2003-01-01" @default.
- W2386179670 modified "2023-09-22" @default.
- W2386179670 title "Determination of ibudilast in human plasma by HPLC" @default.
- W2386179670 hasPublicationYear "2003" @default.
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