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- W2386180985 abstract "AIM: To observe the effect of oxymatrine on sodium channel in isolated cardiomyocytes of guinea pig. METHODS: Single ventricular myocytes of guinea pigs were obtained by enzymatic dissociation. The whole - cell patch clamp recording technique was used to record the change of sodium current by different dosage of oxymatrine from 1 to 1 000 μmol·L-1 . RESULTS: Oxymatrine decreased sodium current in a dose - dependent manner. Oxymatrine (100 μmol·L-1) decreased the current density by 40% (P 0.01). The current - voltage curve was moved up and active potential, peak potential and reverse potential had no change. The inactivation curve was moved to more negative potential and the recovery curve was delayed. The activation curve had no significant change. CONCLUSION: Oxymatrine decreases the sodium channel current in a dose - dependent and voltage - dependent manner." @default.
- W2386180985 created "2016-06-24" @default.
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- W2386180985 date "2005-01-01" @default.
- W2386180985 modified "2023-09-23" @default.
- W2386180985 title "Effect of oxymatrine on sodium channel in isolated ventricular myocytes in guinea pig" @default.
- W2386180985 hasPublicationYear "2005" @default.
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