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- W2386189842 abstract "Objective:To observe the effects of N-(4-Hydroxyphenyl)retinamide(4-HPR)induced apoptosis in vitro in A549,a human alveolar adenocarcinoma cell line,and its inducing mechanisms in the cells.Methods: A549 cells were treated with different concentrations of 4-HPR for observation of the cellular morphology and inhibitory effects by inverted microscope and detection of the apoptosis by Hoechst 33258 staining through a fluorescent microscope.Western blot was used to examine the expression of the proteins associated with apoptosis Bax/Bak.Results: Increased concentration of 4-HPR treatment resulted in the cell decrease,loss of normal growth,blurred glossiness and small and round configuration,and yet enhanced degree of apoptosis which was grossly seen swollen and round nuclei,densified staining or fragmentation.4-HPR treatment also led to a significant increase in Bax/Bak and P53 levels.Conclusion: 4-HPR can significantly inhibit the proliferation and induce apoptosis of A549 cells through protein Bax/Bak and P53 expression enhancement,which may lay the foundation for the laboratory work for further investigation of 4-HPR mechanisms associated with the therapy of pulmonary adenocarcinoma." @default.
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- W2386189842 date "2011-01-01" @default.
- W2386189842 modified "2023-09-23" @default.
- W2386189842 title "4-HPR effects on apoptosis of A549 in vitro through changing Bax/Bak protein expression" @default.
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