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- W2386190511 abstract "Objective To explore the effect of artemether on the development of Plasmodium yoelii in Anopheles stephensi and its mechanism.Methods Basing on Plasmodium yoelii / Anopheles stephensi model,mosquitoes were fed on artemether,which the effect of artemether on the development of Plasmodia was observed.To learn the mechanism of artemether effected the development of Plasmodia,which the transcript variation of NOS,TEP1and PPO was analyzed by using RT-PCR.NOS,TEP1and PPO play important roles in immune response against plasmodia infection.Results Artemether enhanced the development of Plasmodium yoelii in Anopheles stephensi,and made the oocysts increase 3-to 5-folds.RT-PCR results showed that artemether inhibited the expression of NOS,TEP1 and PPO.Our research suggested that artemether may weaken Anopheles stephensi immune response against Plasmodium by inhibiting NO synthesis and melanization or lysis,which resulted in better development of Plasmodium in Anopheles stephensi.Conclusion Our research suggested that artemether may inhibit the expression of immune genes of mosquites,which results in better development of Plasmodium yoelii in Anopheles stephensi." @default.
- W2386190511 created "2016-06-24" @default.
- W2386190511 creator A5082874122 @default.
- W2386190511 date "2011-01-01" @default.
- W2386190511 modified "2023-09-23" @default.
- W2386190511 title "Effect of artemether on the development of Plasmodium yoelii in Anopheles stephensi" @default.
- W2386190511 hasPublicationYear "2011" @default.
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