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- W2386193013 abstract "Objective:To study the mechanism of proliferation inhibition and apoptosis of murine marcrophage-like cell line RAW264.7 cells induced by Pneumolysin(Ply).Methods:Protein Ply was added into culture supernatant of RAW264.7 cells and cocultured with the cells.The growth inhibition rate of RAW264.7 cells was measured by MTT.The apoptosis rate of RAW264.7 cells was examined by Annexin V-FITC/PI-stain.The activity of Caspase-3,8,9 was detected by spectrophotometry.The expressions of Bax,Fas,Bcl-2 were investigated by immunocytochemistry.Results:Ply presented the apparent proliferation inhibition on RAW264.7 cells in a time-and dose-dependent manner.The typical morphological features of apoptosis were observed after Ply treatment at 1 μg/ml for 24 h.And the apoptosis rate of RAW264.7 cells was 32.90% and 51.56% after Ply treatment at 1 μg/ml for 1 h and 3 h respectively(P0.05).The activity of Caspase-3,8,9 was increased compared with control after Ply treatment at 1 μg/ml for 24 h(P 0.05).The expression of Bax,Fas was increased,while the expression of Bcl-2 was reduced compared with control(P0.01).Conclusion:Ply induced apoptosis in murine RAW264.7 cells through death receptor/Fas and mitochondrial pathway." @default.
- W2386193013 created "2016-06-24" @default.
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- W2386193013 date "2012-01-01" @default.
- W2386193013 modified "2023-09-26" @default.
- W2386193013 title "Pneumolysin induced apoptosis in murine RAW264.7 cells through death receptor/Fas and mitochondrial pathway" @default.
- W2386193013 hasPublicationYear "2012" @default.
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