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- W2386200171 abstract "Objective To determine if hemin pretreatment has protective effects on the lungs in a rat model of septic shock.Methods Twenty healthy SD rats of both sexes aged 2.0-2.5 months, weighing 160-185 g were randomly divided into 2 groups (n=10): septic shock group (S) and hemin pretreatment group (H) . Septic shock was induced by intravenous LPS 10 mg·kg-1 in both groups. 24 h before induction of septic shock group H received hemin 100 mg·kg-1 intraperitoneally while group S received normal saline instead of hemin. Common carotid artery and external jugular vein were cannulated and hooked up to Hellige monitor. Evans blue 30 mg·kg-1 was given i.v. 5 min before LPS administration. The animals were sacrificed 6 h after intravenous LPS. The lungs were immediately removed for the determination of lung water content, SOD activity. Evans blue and malondialdehyde (MDA) contents, expression of HO-1 mRNA, HO-2 mRMA, and HO-1 protein, HO-2 protein levels. Results The lung water ratio (wet-dry lung weight/wet lung weight). Evans blue and MDA contents were significantly lower while SOD activity was significantly higher in group H than in group S (P 0.05, 0.01). The HO-1 mRNA expression and HO-1 protein level were significantly higher in group H than in group S; but there was no significant difference in HO-2 mRNA expression and HO-2 protein level between the two groups. Conclusion The HO-1 protein induced by hemin pretreatment may contribute to the protection of the lung during septic shock." @default.
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- W2386200171 date "2004-01-01" @default.
- W2386200171 modified "2023-09-25" @default.
- W2386200171 title "Protective effects of hemin pretreatment on the lungs in a rat model of septic shock" @default.
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