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- W2386226008 abstract "Objective To test the cellular sources of signals released by peripheral immune system and transformed by the neuroimmunoregulation network,and to compare functional differences in central nervous system(CNS) related to neuroimmune regulations between Balb/c mice and Balb/c-nu mice in different immune states.Methods Fifty Balb/c mice and fifty Balb/c-nu mice were randomly divided into the immune 2,4,6 and 8 days' groups and the control group(10 cases in each group).Immunohistochemical techniques were used to observe expression levels of interleukin-1β(IL-1β) in encephalic regions of neuroimmune regulation [lateral hypothalamic area(LH) and anterior amygdaloid area(AA)] at different immune time.SPSS11.0 was used to analyze variance.The effect of T cells defect on neuroimmunoregulation was analyzed.Results The immunized Balb/c mice expressed more IL-1β in the LH,AA regions compared with the control group(P0.05).The level of IL-1β increased on the 2nd day after immunization,and reached the peak on the 4th day,then started to decline on the 6th day(P0.05,respectively)and returned to physiological level on the 8th day(P0.05).Balb/c-nu mice experienced the similar procedures as the Balb/c mice,while immunized Balb/c-nu mice expressed lower levels of IL-1β than immunized Balb/c mice at the same time point(P0.05).Conclusions Balb/c mice and Balb/c-nu mice can both initiate neuroimmunoregulation responses in LH,AA areas after injected with antigens.Dendritic cells(DCs) and Th cells both present neuroimmunoregulation signals to CNS after activation of the immune system and this presentation mainly relies on DCs." @default.
- W2386226008 created "2016-06-24" @default.
- W2386226008 creator A5027932256 @default.
- W2386226008 date "2012-01-01" @default.
- W2386226008 modified "2023-09-27" @default.
- W2386226008 title "Cell sources of the afferent signals in neuroimmune regulation network" @default.
- W2386226008 hasPublicationYear "2012" @default.
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