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- W2386248110 abstract "Background and purpose:Because of the heterogeneity of cancers,different patients with the same kind of cancer have different sensitivity for cytotoxic drugs.Newly developed ATP chemosensitivity assays(ATPTCA) offer the opportunity for individualized therapy and have shown promising results compared to standard regimens.We explored the feasibility of the ATP-Tumor Chemosensitivity Assay(ATP-TCA) applied in the treatment of ovarian cancer with chemotherapy,and evaluate the in vitro sensitivity of fresh specimens of ovarian cancer to five cytotoxic drugs.Methods:ATP-TCA was used to detect the sensitivity rate of 24 fresh specimens of ovarian cancer to five cytotoxic drugs as follows: paclitaxel(TAX),gemcitabine(GEM),doxorubicin(ADM),topotecan(TPT),cisplatin(DDP).Results:23 of 24 specimens((95.83%)) can be evaluated by ATP-TCA,the sensitive rates of ATP-TCA was 91.30% for TAX,86.96% for GEM,65.22% for ADM,47.83% for TPT and 21.74% for DDP,respectively.Conclusions:ATP-TCA was a sensitive、reliable and standardized method for the evaluation of tumor chemosensitivity,it ts worthwhile to investigate further for the application screening anticancer agents in chemotherapy of ovarian cancer." @default.
- W2386248110 created "2016-06-24" @default.
- W2386248110 creator A5074082072 @default.
- W2386248110 date "2006-01-01" @default.
- W2386248110 modified "2023-09-24" @default.
- W2386248110 title "Application of ATP-tumor chemosensitivity assay in primary epithelial ovarian cancer(PEOC)" @default.
- W2386248110 hasPublicationYear "2006" @default.
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