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- W2386249151 abstract "Objective To investigate the immuno-protective effect of UV-attenuated oncospheres of Taenia asiatica in domestic pigs. Methods UV-attenuated oncospheres were injected in domestic pigs via the auricular vein,and an ELISA kit was used to determine serum levels of IgG pre-and post-immunization.Levels of IL-4and INF-γsecreted by splenocytes exposed to mitogen Con A were determined.The number of cysticerci and state of their development were compared in immunized pigs and control pigs on day 15and day 45after the challenge. Results Serum levels of IgG in pigs increased on day 10after immunization and were significantly higher on day 35than they were prior to immunization(t=9.312,P0.05).After splenocytes were cultured for 24h,the supernatant level of IL-4was higher for immunized pigs than for control pigs(F=10.45,P0.05)although the level of INF-γdid not differ significantly for the two groups(F=2.456,P0.05).After splenocytes were exposed to mitogen Con A for 24h,the supernatant level of IL-4was higher for immunized pigs than for control pigs(F=32.82,P0.05),but the level of INF-γdid not differ significantly for the two groups(F=7.17,P0.05).The total cysticercus count and mature cysticercus count decreased in immunized pigs while the number of degenerated or calcified cysticerci increased on day 15after the challenge.There were no cysticerci in immunized pigs on day 45after the challenge. Conclusion Immunization with UV-attenuated oncospheres of T.asiaticainduced a moderate level of immuno-protection in domestic pigs." @default.
- W2386249151 created "2016-06-24" @default.
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- W2386249151 date "2014-01-01" @default.
- W2386249151 modified "2023-09-26" @default.
- W2386249151 title "The immuno-protective effect of UV-attenuated Taenia asiatica oncospheres in domestic pigs" @default.
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