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- W2386256366 abstract "Objective To investigate the expression and distribution of cyclin-dependent kinase 5 (CDK5) mRNA in the developmental brain in mice. Methods Embryonic to aged stage murine embryo and brain sections were stained by whole-mount in situ hybridization technique. Results The expression of CDK5 specific mRNA, distributed mainly in the neuroepithelial mantle layer, was detected in the brain tissue from E10.5 d by whole mount in situ hybridization. Higher and stable levels of CDK5 mRNA were detected from E14 d to adulthood mice. The cellular location of the CDK5 mRNA was confined to both nucleus and cytoplasm. The peak of CDK5 expression was around the prenatal and postnatal periods. The main distribution regions of CDK5 mRNA included the cerebral cortex, hippocampus, thalamus, hypothalamus, cerebellum, and several neural nucleus masses. In the aged brains, the expression of CDK5 mRNA decreased, and some regions were negative or weakly stained. Conclusion The results indicate that the changes of CDK5 expression are parallel to the development of nervous system. CDK5 may be involved in the whole neurodevelopmental stages of brain, especially in the early development of nervous system. CDK5 expression in the adult may be closely associated with the regulatory function of neurons in some regions." @default.
- W2386256366 created "2016-06-24" @default.
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- W2386256366 date "2004-01-01" @default.
- W2386256366 modified "2023-09-25" @default.
- W2386256366 title "Changes of cyclin-dependent kinase 5 mRNA expression are involved in the development of brain in mice" @default.
- W2386256366 hasPublicationYear "2004" @default.
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