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- W2386271090 abstract "AIM: To compare the pharmacokinetic parameters of the two kinds of omeprazole capsules, following per oral administration. METHODS: Twenty healthy volunteers were per orally cross-administrated two kinds of omeprazole two capsules (20 mg omeprazole per capsule). The plasma concentrations of omeprazole were determined by the reverse phase high performance liquid chromatography (RP-HPLC) method. The pharmacokinetic parameters of two capsules preparations were calculated and compared by 3P97 Software. RESULTS: The concentration-time curve of omeprazole complied with the single compartment model. Following per oral administration of omeprazole 40 mg, there were no statistical significant differences of the main pharmacokinetic parameters between the two capsules preparations by the analysis of variance (P0.05). The relative biological availabilities of the two capsules preparations were (95.5-110.7) %. CONCLUSION: The results demonstrate that the two kinds of omeprazole capsules are bioequivalent." @default.
- W2386271090 created "2016-06-24" @default.
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- W2386271090 date "2002-01-01" @default.
- W2386271090 modified "2023-09-26" @default.
- W2386271090 title "Pharmacokinetic parameters comparison of two kinds of omeprazole capsules" @default.
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